博士，研究员，博士生导师。2006年获北京大学生命科学学院学士学位；2012年获密歇根大学博士学位。2011年获得国家留学基金委自费留学生奖学金“特别优秀奖”。2012年加入中国科学院遗传与发育生物学研究所，2014年入选“青年千人计划”。中国生物化学与分子生物学会分子系统生物学专业委员会委员。主要从事系统生物学和比较基因组学研究，在基因组进化机制、单细胞转录组和翻译组学方面取得了多项研究成果。作为通讯作者在Genome Res、Genome Biol、Mol Biol Evol、PLoS Comput Biol等杂志上发表论文7篇。
Dissecting the transcription regulation of abiotic stress response in rice at the single-cell resolution.
Plants cope with environmental stresses partly by changing transcription profiles. As a result, transcriptome analyses have been extensively performed to study the gene expression regulation upon stress. However, the bulk transcriptome analysis that previously performed ignored the cell-type specificity; a change in average expression level can be from the change in gene expression among a subset of cells, the change in the number of cells that express the gene, or both. To tackle this problem, we performed single-cell RNA-seq in the aerial part of the wild-type japonica (spp. Nipponbare), in the normal lab condition, as well as being treated with the increase of salinity level and nitrogen deficiency, respectively. We observed various response patterns of transcriptome among cell types. However, the gene expression response was largely shared between the two abiotic stresses. Furthermore, we observed a decrease in the number of mesophyll cells and an increase in the number of parenchymal cells under both stresses, suggesting that cell division and differentiation also play a role in stress response. Our study opens a new layer of regulation in response to abiotic stresses in rice.